Role of p300 in susceptibility of atrial Hbrillation in aged mice
- Author:
De-Wei PENG
1
;
Hui-Shan ZHOU
1
;
Xiao-Yan GAO
1
;
Qiao-Qiao LI
1
;
Chun-Yu DENG
1
;
Shu-Lin WU
1
;
Fang RAO
1
;
De-Wei PENG
2
;
Hui-Shan ZHOU
2
;
Hai-Yan LIU
2
;
Xiao-Yan GAO
2
;
Ying-Yu LAI
2
;
Qiao-Qiao LI
2
;
Chun-Yu DENG
2
;
Hui YANG
2
;
Su KUANG
2
;
Yu-Mei XUE
2
;
Shu-Lin WU
2
;
Fang RAO
2
;
Ying-Yu LAI
3
Author Information
- Publication Type:Journal Article
- Keywords: action potential duration; aging; atrial myocytes; curcumin; L-type calcium current; p300
- From: Chinese Pharmacological Bulletin 2021;37(2):180-186
- CountryChina
- Language:Chinese
- Abstract: Aim To explore the role of cotranscriptional activator p300 in regulating the electrical remodeling of atrial myocytes in aging mouse, which resulted in atrial fibrillation. Methods The left atrial appendage tissues of 5 , 13 and 18monthold C57BL/6 mice were collected respectively. Western blot was used to detect the protein expression levels of p300, L type calcium channel (Cavl. 2) and aging related protein p53/p21. Acute enzymatic hydrolysis was used to isolate single atrial myocytes, and the wholecell patchclamp technique was used to detect the Ltype calcium current (I
