Evodiamine induces apoptosis of leukemia cell line K562 VIA modulation of TRIB2/AKT pathway

Author: Feng-Lin MOU ¹ ; Bei-Zhong LIU ¹ ; Jian LI ¹ ; Liang ZHONG ¹ ; Jiao YE ¹ ; Bei-Zhong LIU ² ; Li-Hua YU ² ; Wen-Ran DAN ² ; Ling XIONG ²
Author Information

1. Key Lab of Clinical Laboratory Diagnostics, Ministry of Education, Chongqing Medical University
2. Yongchuan Hospital, Chongqing Medical University
Publication Type:Journal Article
Keywords: AKT; apoptosis; evodiamine; K562 cell; proliferation suppression; TRIB2
From: Chinese Pharmacological Bulletin 2021;37(1):118-124
CountryChina
Language:Chinese
Abstract: Aim To investigate the effects of Evodiamine (EVO) on proliferation and apoptosis of human leukemia cell line K562 and its potential mechanisms. Methods K562 cells were treated with EVO at different concentrations (0, 1, 2, 4, 8, 16, 32, 64 jxmol • L