Dihydromyricin inhibited hepatic lipid deposition induced by high-fat diet in obese mice by activating SIRT1-AMPK pathway

Author: Zi-Han WANG ¹ ; Jin-Ding LUO ¹ ; Hui-Jie LYU ¹ ; Jian-Qin HE ¹ ; Hong-Yan LING ¹ ; Ying-Ru TIAN ² ; Shui-Dong FENG ³
Author Information

1. Dept of Physiology, Hengyang Medical College, University of South China
2. Clinical Class 21, Grade 2017, Hengyang Medical College, University of South China
3. Dept of Social Medicine and Health Management, Public Health College, University of South China
Publication Type:Journal Article
Keywords: dihydromyricetin; hepatic lipid deposition; lipid decomposition; lipid synthesis; obesity; SIRT1-AMPK pathway
From: Chinese Pharmacological Bulletin 2021;37(1):107-113
CountryChina
Language:Chinese
Abstract: Aim To investigate the effect of dihydromyricetin (DHM) on lipid accumulation in liver of obese mice induced by high fat diet and its mechanism. Methods Sixty C57BL/6J mices were randomly divided into six groups (n = 10); (1)ND group; normal diet, (2)ND + L-DHM group; normal diet and treatment with low-dose DHM (125 mg • kg