Rosuvastatin relieves neuronal mitochondrial damage by regulating UCP2-SIRT3 pathway after cerebral ischemia/reperfusion
10.3969/j.issn.1001-1978.2021.01.010
- Author:
Xue-Jia DONG
1
;
Ming-Fang JIANG
2
;
Li-Dao BAO
3
Author Information
1. Graduate School
2. Dept of Neurology, Affiliated Hospital
3. Dept of Pharmacology, School of Basic Medical Sciences, Inner Mongolia Medical University
- Publication Type:Journal Article
- Keywords:
cerebral ischemia/reperfusion;
Drpl;
mitochondrial damage;
Opal;
rosuvastatin;
TOMM20;
UCP2/SIRT3 pathway
- From:
Chinese Pharmacological Bulletin
2021;37(1):52-61
- CountryChina
- Language:Chinese
-
Abstract:
Aim To explore the biological role and related mechanism of rosuvastatin (RS) in mitochondrial damage of neurons after cerebral ischemia/reperfusion (CIR) through UCP2-SIRT3 signaling pathway. Methods Human neuroblastoma cell (SH-SY5Y cell) cerebral infarction reperfusion model (OGD/R) was established, different concentrations of RS (40 and 2. 5 (mol • L
