Role and treatment of ARIDIA in mutant tumors
10.3969/j.issn.1001-1978.2021.01.001
- Author:
Li-Ying MA
1
;
Guo-Zheng CAO
1
;
Wen-Chu LIN
1
;
Li-Ying MA
2
;
Guo-Zheng CAO
2
Author Information
1. High Magnetic Field Lab, Chinese Academy of Sciences
2. University of Science and Technology of China
- Publication Type:Journal Article
- Keywords:
ARIDIA;
Progress research;
SWI / SNF complex;
Synthetic lethal;
Targeted therapy;
Tumor suppressor gene
- From:
Chinese Pharmacological Bulletin
2021;37(1):1-5
- CountryChina
- Language:Chinese
-
Abstract:
ARIDI A encodes a non-catalytic subunit of SWI/SNF chromosome remodeling complex BAF. Cancer genome sequencing data based on next-generation sequencing techniques have shown that ARIDIA is frequently mutated in a variety of cancers, up to 20% in some cancer types. A growing body of evidence shows that ARIDIA, as a tumor suppressor gene, affects the occurrence and development of cancers. ARIDIA plays an important role in cell cycle, DNA replication, DNA repair and transcriptional regulation, which might contribute to tumor formation, proliferation and migration. This review article mainly describes the research progress on ARIDIA in pan-cancer, as well as potential therapeutics, hoping to provide new ideas for the diagnosis and treatment of tumors.
