The protective effect of Medicoscab Tincture on deep partial thickness burn rats and its mechanism
10.3969/j.issn.1001-1978.2021.08.023
- Author:
Fei-Long LI
1
;
Zhao-Gang HUANG
1
;
Gang CHENG
1
;
Quan XIA
1
;
Fei-Long LI
2
;
Zhao-Gang HUANG
2
;
Gang CHENG
2
;
Jun LI
2
;
Quan XIA
2
;
Jin-Ping GAO
3
;
Di-Di ZHAN
4
Author Information
1. the Grade 3 Pharmaceutical Chemistry Laboratory of State Administration of Traditional Chinese Medicine, the First Affiliated. Hospital of Anhui Medical University, Dept of Pharmacy
2. School of Pharmacy, Anhui Medical University
3. Institute of Dermatology and Dept of Dermatology, the First Affiliated Hospital of Anhui Medical University
4. Anhui Provincial Children's Hospital, Dept of Pharmacy
- Publication Type:Journal Article
- Keywords:
burn;
deep partial thickness burn;
inflammation mediator;
Medicoscab Tincture;
ROS;
wound healing
- From:
Chinese Pharmacological Bulletin
2021;37(8):1164-1168
- CountryChina
- Language:Chinese
-
Abstract:
Aim To investigate the effect of Medi- coscab Tincture could increase the healing rate of burn coscab Tincture on the wound repair of deep partial thickness burn in rats and its possible mechanism. Methods SD100 rats were used to make a rat model of deep partial thickness burn. The rats were randomly divided into five groups; normal, model control, positive control, Medicoscab Tincture high-dose, and Medicoscab Tincture low-dose. The dosing group was changed daily for 14 consecutive days. The healing rate and water content of wound were measured at 3 d, 7 d and 14 d after burn. The activities of superoxide dismutase (SOD) and catalase (CAT) and the content of malondialdehyde ( MDA) were determined by bio-chemical analysis. Serum levels of tumor necrosis fac- tor-a (TNF-a), interleukin-1 (3 (IL-1(3) and interleu- kin-6 (IL-6) in rats were determined. Results Medi- wound and decrease the water content of burn wound tissue in rats ( P < 0. 05 ). The activity of SOD significantly increased, the content of MDA decreased (P < 0. 05), and the contents of TNF-a, IL-1 (3 and IL-6 in serum of burned rats decreased ( P < 0. 05, P < 0.01). Conclusions Medicoscab Tincture can improve the wound healing rate, reduce the wound water content, increase SOD activity, reduce the content of MDA in the wound, and reduce the serum levels of inflammatory factors TNF-a, IL-1 (3 and IL-6. Therefore, Medicoscab Tincture has a protective effect on deep partial thickness burn in rats.
