Effect of p-coumaric acid on olfactory bulbectomy induced depression-like behaviors and its AMPA receptor mechanism in mice
10.3969/j.issn.1001-1978.2021.08.012
- Author:
Xu-Hui XIAO
1
;
Hui-Rong LI
1
;
Jin-Cheng LI
1
;
Chu-Li XIAO
1
;
Xu-Hui XIAO
2
;
Hui-Rong LI
2
;
Chu-Li XIAO
2
;
Zhi-Yong XIAO
3
Author Information
1. Basic Medical School, Shaoyang University
2. Hunan Engineering Research Center for Development and Utilization of Traditional Chinese Medicine in Southwest of Hunan
3. University of South China, the First Affiliated Hospital
- Publication Type:Journal Article
- Keywords:
AMPA receptor;
CX546;
depression-like behaviors;
NBQX;
olfactory bulbectomy;
p-coumaric acid
- From:
Chinese Pharmacological Bulletin
2021;37(8):1099-1103
- CountryChina
- Language:Chinese
-
Abstract:
Aim To investigated the effect of p-CA on depression-like behaviors of mice of olfactory bulbectomy and its possible mechanism. Methods The olfactory bulbectomy (OBX) model of mice was established by an operation of olfactory bulbectomy. The behaviors of the mice were detected by the forced swimming test and the tail suspension test. Results The depression-like behavior in the forced swimming and tail suspension test and the in the open field test significantly increased in OBX mice; however, p-CA improved the depres- sion-like behavior in the forced swimming and tail sus pension test and the hyper-locomotor activity in open field test in OBX mice. Moreover, treatment with AMPA receptor antagonist NBQX blocked this improving effect of p-CA. While, treatment with AMPA receptor agonist CX546 enhanced this improving effect of p-CA. Conclusions P-CA improves depression-like behaviors of OBX mice, and AMPA receptors may mediate this effect.
