Advances on experimental models of rheumatoid arthritis
10.3969/j.issn.1001-1978.2021.11.003
- Author:
Li-Qing LI
1
;
Qian-Ying LUO
1
;
Li-Qing LI
2
;
Feng ZHANG
2
;
Fu-Zhi PENG
2
;
Xin LI
2
;
Liang LIU
2
;
Liang LIU
3
Author Information
1. Guangxi Provincial Key Laboratory of Preventive and Therapeutic Research in Prevalent Diseases in West Guangxi, Youjiang Medical University for Nationalities
2. Institute of Innovation and Applied Research in Chinese Medicine, Hunan University of Chinese Medicine
3. State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology
- Publication Type:Journal Article
- Keywords:
animal models;
autoimmune diseases;
drug screening;
pathogenesis;
pathological features;
rheumatoid arthritis
- From:
Chinese Pharmacological Bulletin
2021;37(11):1492-1497
- CountryChina
- Language:Chinese
-
Abstract:
Rheumatoid arthritis (RA) is a chronic immune-me- diated synovial disease with unknown aetiology, therefore, it is considered a chronic disease that cannot be cured. RA is caused by a complex interaction between genetic and environmental factors. As such long-standing efforts have been made for better understanding of disease pathogenesis and the development of new classes of therapeutics, the continuing elucidation of pathogenic events underlying RA mostly relies on animal model studies. Individually animal models allow molecular and spatiotemporal dissection of various pathological processes of RA development. We have herein comprehensively discussed different animal models in induction methods, pathogenesis, pathological events and disease characteristics, hoping to provide the basis and reference for the rational selection of experimental animal models for the basic research and drug screening of RA.
