Efficacy and safety of alfentanil hydrochloride injection in general anesthesia: A multicenter, double-blind, controlled study

Ming-hua Chen; Yi Feng; Kai-ming Duan; Wen Ouyang; Sai-ving Wang; Fu-shan Xue; Ming-hua Chen; Fu-shan Xue; Yi Feng; Ai-lin Luo; Qu-lian Guo; Ya-ping Wang; Deng-bin AI; Gong-jian Liu; Kai-ming Duan; Wen Ouyang; Sai-ving Wang; Ai-lin Luo; Qu-lian Guo; Ya-ping Wang; Deng-bin AI; Gong-jian Liu

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Efficacy and safety of alfentanil hydrochloride injection in general anesthesia: A multicenter, double-blind, controlled study

Author: Ming-Hua CHEN ¹ ; Yi FENG ¹ ; Kai-Ming DUAN ¹ ; Wen OUYANG ¹ ; Sai-Ving WANG ¹ ; Fu-Shan XUE ² ; Ming-Hua CHEN ³ ; Fu-Shan XUE ³ ; Yi FENG ³ ; Ai-Lin LUO ³ ; Qu-Lian GUO ³ ; Ya-Ping WANG ³ ; Deng-Bin AI ³ ; Gong-Jian LIU ³ ; Kai-Ming DUAN ³ ; Wen OUYANG ³ ; Sai-Ving WANG ³ ; Ai-Lin LUO ⁴ ; Qu-Lian GUO ⁵ ; Ya-Ping WANG ⁶ ; Deng-Bin AI ⁷ ; Gong-Jian LIU ⁸
Author Information

1. Central South University, Third Xiangya Hospital, Dept of Anesthesiology
2. Capital Medical University, Dept of Anesthesiology Y Beijing Friendship Hospital
3. Dept of Anesthesiology Y Peking University People's Hospital
4. Tongji Medical College, Huazhong University of Science and Technology, Tongji Hospital, Dept of Anesthesiology
5. Department of Anesthesiology, Central South University, Xiangya Hospital
6. Central South University, Second Xiangya Hospital, Dept of Anesthesiology
7. Qingdao Municipal Hospital, Dept of Anesthesiology
8. Dept of Anesthesiology, Affiliated Hospital of Xuzhou Medical University
Publication Type:Journal Article
Keywords: alfentanil; blood pressure; endotracheal intubation; general anesthesia; gentanyl; heart rate
From: Chinese Pharmacological Bulletin 2022;38(10):1504-1510
CountryChina
Language:Chinese
Abstract: Aim To investigate the effectiveness and safety of alfentanil in general anesthesia.Methods In this study, a multicenter randomized double-blind con¬trolled study was conducted.A total of 352 subjects were selected and randomly assigned to fentanyl group (group A, n =176) and alfentanil group (group 15, n = 176).Anesthesia induction: intravenous midazolam 0.03 mg • kg-1 + fentanyl 25 p.g • kg"'(group A) or alfentanil 4 p,g • kg-1 ( group 15) + propofol 2 mg • kg"1 + rocuronium 0.8 mg • kg"1.Sevoflurane + fent¬anyl ( group A ) or alfentanil ( group B ) + rocuronium were used for anesthesia.The vital signs of patients re¬covery time and extuhation time, anesthesia-related complications and the use of related remedial drugs during anesthesia induction and maintenance were compared between the two groups.Results During the induction and maintenance period of anesthesia, alfentanil and fentanyl could equally effectively inhibit the stress response induced by endotracheal intubation and surgical stimulation.Alfentanil also showed more effective inhibition on stress response induced by endo¬tracheal intubation and surgical stimulation than that of fentanyl ( P < 0.05 ) .However, there was no signifi¬cant difference in the incidence of intraoperative hypo¬tension and hypertension and the time of anesthesia re¬covery and extubation between the two groups.Conclu¬sions Both alfentanil and fentanyl can effectively in¬hibit the stress response induced by surgical stimulation and could be safely used in general anesthesia in sur¬gery.Alfentanil has more advantages in maintaining the stability of blood pressure and heart rate during an¬esthesia induction and maintenance.