Research progress on pharmacological effect of evodiamine

Jing-rong Liang; Chen-guang LI; Zhi-guo Zhang; Jing-rong Liang; Chen-guang LI; Xiang Liao; Feng-yi Mai

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Research progress on pharmacological effect of evodiamine

Author: Jing-Rong LIANG ¹ ; Chen-Guang LI ¹ ; Zhi-Guo ZHANG ¹ ; Jing-Rong LIANG ² ; Chen-Guang LI ² ; Xiang LIAO ² ; Feng-Yi MAI ³
Author Information

1. Shenzhen University Health Science Center, School of Biomedical Engineering
2. Huazhong University of Science and Technology Union Shenzhen Hospital, Pain Management
3. Southern University of Science and Technology, Dept of Medicine
Publication Type:Journal Article
Keywords: Euodiae Fructus; evodiamine; pharmacological activities; protein targets; research progress; safe medication
From: Chinese Pharmacological Bulletin 2022;38(10):1457-1461
CountryChina
Language:Chinese
Abstract: Evodiamine(EVO)is an indoloquinazoline alkaloid isolated from the fruits of Euodia rutaecarpa,which has long been used in traditional Chinese medicine to treat various diseases.Modern medical research shows that evodiamine has various pharmacological activities and extremely high medicinal value such as anti-inflammation,anti-tumor,losing weight,treating Alzheimer's,and antibacterium.Evodiamine can interact with a variety of proteins.For example,the interaction between evodiamine and TRPV1 induces its activation to exert anti-inflammatory and losing weight; the interaction with DNA topoisomerase I inhibits its function and thus inhibit bacterial proliferation; the interaction with tubulin promotes NLRP3 inflammasome activation,and exerts anti-tumor and anti-inflammatory functions.In recent years,with the in-depth study of evodiamine,pharmacological research and mechanism of evodiamine has significant improvement.Recent progress of pharmacological effect of evodiamine is highlighted in this review.