Periostin-a potential molecular marker for early diagnosis of disease

Author: Xin ZHOU ¹ ; Lu XING ¹ ; Chun-Xia HE ¹ ; Hui-Jin LI ¹ ; Wei QIN ¹ ; Dong ZHAO ¹ ; Peng-Quan LI ¹ ; Li ZHU ¹ ; Hui-Ling CAO ¹
Author Information

1. Institute of Basic and Translational Medicine, Ai' An Medical University, Shaanxi Key Laboratory' of Ischemic Cardiovascular Disease
Publication Type:Journal Article
Keywords: cancer; chronic nephrosis; molecular marker; myocardial infarction; POSTN; vascular calcification
From: Chinese Pharmacological Bulletin 2022;38(5):650-654
CountryChina
Language:Chinese
Abstract: Periostin (POSTN), an evolutionary conserved and secreted extracellular matrix protein, can be easily detected by humoral samples such as blood, urine, interstitial fluid etc., which was firstly found in bone tissues.POSTN is expressed in various tissues and its expression level is closely related to oc¬currence and development of various diseases, which will be a potential molecular marker in early diagnosis of diseases.'Hie paper systematically summarizes the relationship of the expres¬ sion level of POSTN and some diseases including myocardial in¬farction, vascular calcification, diseases related to bone metabo¬lism, chronic nephrosis and various cancers, and explores its function as well as mechanism, which provides scientific basis for the early diagnostic kits or new drug development of diseases based on POSTN.