Research progress in nephrotoxicity and prevention of arsenic trioxide

Author: Rui KAN ¹ ; Rui ZHONG ¹ ; Jing LIU ¹ ; Zhi-Gui WU ¹ ; Cai-Ying PENG ¹ ; Hong CHEN ¹ ; Xiao-Mei FU ¹ ; Zhi-Gui WU ² ; Xiao-Mei FU ²
Author Information

1. Jiangxi University of Chinese Medicine
2. Fan Cuisheng Studio of National Famous Traditional Chinese Medicine
Publication Type:Journal Article
Keywords: acute promyelocytic leukemia; apoptosis; arsenic trioxide; methylation; nephrotoxicity; oxidative stress
From: Chinese Pharmacological Bulletin 2022;38(2):177-180
CountryChina
Language:Chinese
Abstract: Aim Arsenic trioxide (ATO, As203 ) can effectively treat acute promyelocyte leukemia (APL) and other malignant tumors.However.ATO has been found to have nephrotoxic effects during the treatment process, which limits the clinical application of ATO.Studies have shown that the use of ATO can interfere with the body's oxidation, causing to oxidative stress, damage DNA repair pathways, and induce DNA mutations.leading to cell cancer.This is currently one of the important mechanisms of ATO nephrotoxicity.Apoptosis, DNA methyl a- tion caused by ATO are also causes of nephrotoxicity.This article summarizes the research and prevention of ATO nephrotoxicity mechanism.