Exploration of potential molecular mechanism of Chuanxiong in treatment of tension-type headache based on network pharmacology and molecular docking
10.3969/j.issn.1001-1978.2022.01.025
- Author:
Chun-Long HAN
1
;
Xin-Jie ZHAO
1
;
Chen BAI
1
;
Meng-Jun LI
1
;
Wen-Hui LI
2
;
Xiang-Zhe LIU
3
Author Information
1. Lie Nan University of Traditional Chinese Medicine
2. Institute of Biology, IlenanAcademy of Sciences
3. Neurology First Ward of First Affiliated Hospital of i Lenan University of Tcm
- Publication Type:Journal Article
- Keywords:
Chuanxiong;
mechanism of action;
molecular docking;
network pharmacology;
pharmacology of traditional Chinese medicine;
tension-type headache
- From:
Chinese Pharmacological Bulletin
2022;38(1):140-147
- CountryChina
- Language:Chinese
-
Abstract:
Aim To analyze the active ingredients of Chuanxiong, predict its target and signaling pathways in the treatment of tension-type headache, and clarify its therapeutic mechanism based on the principle of network pharmacology.Methods The effective active ingredients in Chuanxiong were retrieved from the Chinese herbal system pharmacology platform(TCMSP), and were performed by the ADME screen to collect the potential targets; the existing tension-type headache-related disease targets were collected through the GeneCards database.The targets corresponding to the active ingredients were intersected to obtain the common target as the key target.Cytoscape was used to construct and analyze the visual "drug-active ingredient-target-disease" network, and the String database was used to construct the PPI protein interaction network; through R language the GO function and KEGG pathway enrichment of common targets in the form of bubble graphs were analyzed.Lastly, molecular docking was used for preliminary verification.Results Finally 7 active ingredients, 105 compound targets and 2 139 tension-type headache-related target genes were obtained.There were 54 nodes in the protein interaction network.GO functional enrichment analysis yielded 215 entries, and KEGG pathway enrichment analysis yielded 68 signaling pathways.Molecular docking showed that FA, Chuanxiong quinone, sitosterol, ligustalin had strong affinity with CASP3, MAPK1, MAPK14.Conclusions It is suggested that Chuanxiong may treat tension-type headaches through anti-inflammatory, antioxidant and cytoprotective effects.
