Homeostasis imbalance of metal ions in Alzheimer's disease
10.3969/j.issn.1001-1978.2022.01.003
- Author:
Ya-Nan LIU
1
;
Fen-Xi NIU
1
;
Yue LIU
1
;
Jun GUAN
1
;
Fang FANG
1
Author Information
1. School of Chinese Materia Medica, Beijing University of Chinese Medicine
- Publication Type:Journal Article
- Keywords:
Alzheimer's disease: metal ions;
amyloid (3-protein;
metal ion ehelating agent;
oxidative stress;
traee elements
- From:
Chinese Pharmacological Bulletin
2022;38(1):9-12
- CountryChina
- Language:Chinese
-
Abstract:
Alzheimer's disease is an age-related neurodegenerative disease, and its pathogenesis has not been fully elucidated.In recent years the role of metal ions in the development and de-velopment of Alzheimer's disease has been brought into foeus.This paper reviews the homeostasis imbalance of metal ions, in- eluding the essential metal ions for human body such as Fe~ + / Fe3+ , CuV Cu2 + , Zn2 + , Mg2 + , as well as non-essential metal ions such as Al '+ and Hg"+ , involved in the pathogenesis of AI), aiming to provide research clues for anti-AD dnig targeting metal ions.
