Research progress of dopamine and dopamine receptor in pathogenesis of asthma
10.3969/j.issn.1001-1978.2022.01.002
- Author:
Ao Li-Bin LI
1
;
Na WU
2
;
Xue-Ping YAO
3
Author Information
1. Dept of Histology and Embryology
2. Second Affiliated Hospital of Xinjiang Medical University
3. Functional Center, School of Basic Medical Sciences, Xinjiang Medical University
- Publication Type:Journal Article
- Keywords:
airway epithelial eells;
airway smooth muscle;
asthma;
dopamine reeeptor;
inflammatory faetors;
T helper eells
- From:
Chinese Pharmacological Bulletin
2022;38(1):5-8
- CountryChina
- Language:Chinese
-
Abstract:
Asthma is a common respiratory disease charaeterized by airway inflammation and airway hyperresponsiveness.Dopamine is an important neurotransmitter in human body.In reeent years it has been reported that dopamine reeeptor is expressed in immune eells, type I alveolar eells, airway epithelium and airway smooth muscle, and affects ovalbumin ( OVA )-indueed asthma in animals.This review introduees the role of dopamine in the occurrence and development of asthma from the aspeets of airway inflammation, pulmonary nerve regulation, airway epithelial and smooth muscle abnormalities.
