Research progress of long noncoding RNAs regulating human chondrocyte inflammatory signaling pathways in osteoarthritis
10.3969/j.issn.1001-1978.2022.01.001
- Author:
Ruo-Xue XUE
1
;
Su-An TANG
1
;
Guang-Feng RUAN
1
;
Chang-Hai DING
1
;
Zhao-Hua ZHU
1
Author Information
1. Clinical Research Center of Zhujiang Hospital, Southern Medical University
- Publication Type:Journal Article
- Keywords:
cartilage;
inflammatory signaling pathways;
LncRNAs;
osteoarthritis;
targeted regulation;
therapeutic potential
- From:
Chinese Pharmacological Bulletin
2022;38(1):1-5
- CountryChina
- Language:Chinese
-
Abstract:
Osteoarthritis is the commonest joint disease, but its etiology is still not clear.Recently the role of inflammation in its pathogenesis has been attached increasingly importance.Long noncoding RNAs (LncRNAs) play a key role in regulating the occurrence and development of inflammation-related diseases.This artiele reviews the research progress of LncRNAs in regula ting the occurrence and development of osteoarthritis through various endochondral inflammation signaling pathways in recent years , exploring the application of LncRNAs as a potential therapeutic target in the prevention and treatment of osteoarthritis.
