Research progress on role of autophagy in ADPKD

Bin HE; Yi-vuan Gao; Sheng-gan Shi; Pei-du Jiang; Bin HE; Yi-vuan Gao; Sheng-gan Shi; Pei-du Jiang

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Research progress on role of autophagy in ADPKD

Author: Bin HE ¹ ; Yi-Vuan GAO ¹ ; Sheng-Gan SHI ¹ ; Pei-Du JIANG ¹ ; Bin HE ² ; Yi-Vuan GAO ² ; Sheng-Gan SHI ² ; Pei-Du JIANG ²
Author Information

1. School of Medicine, University of Electronic Science and Technology of China
2. Department of Pharmacy, Personalized Drug Therapy Key Laboratory of Sichuan Province, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Affiliated Hospital of University of Electronic Science and Technology of China
Publication Type:Journal Article
Keywords: autophagy; autosomal dominant polycystic kidney disease; cyst; medicine; mTOR; signaling pathway
From: Chinese Pharmacological Bulletin 2022;38(3):321-325
CountryChina
Language:Chinese
Abstract: Autophagy is a process that delivers cytoplasmic components to lysosome for degradation, which plays an important role in intracellular homeostasis and achieving self-renewal.Recent studies have shown a close relation between autophagy and renal cystogenesis in ADPKD.Further studies show that there are two phenomena of autophagy impairment and autophagy enhancement in the ADPKD disease model.Autophagy disorders influence the occurrence and development of ADPKD.Therefore, the regulation of autophagy may be a new strategy for ADPKD treatment.Medicines that regulate autophagy through mTOR-dependent and mTOR-independent pathways also show a positive effect in alleviating ADPKD symptoms.This paper reviews the progress of the role of autophagy in ADPKD and provides reference for further research of autophagy in ADPKD and its medicine regulation.