Changes of Tear Parameters after Using Cyclosporine A in Dry Eye with Thyroid Ophthalmopahty.
- Author:
Han Jin OH
1
;
In Cheon YOU
;
Kyung Chul YOON
Author Information
1. Department of Ophthalmology, Chonnam National University Medical School & Hospital, Gwangju, Korea. kcyoon@chonnam.ac.kr
- Publication Type:Original Article
- Keywords:
Cyclosporine A;
Ocular surface;
Tear film;
Thyroid-associated ophthalmopathy
- MeSH:
Cyclosporine*;
Fluorescein;
Goblet Cells;
Graves Ophthalmopathy;
Humans;
Metaplasia;
Tears*;
Thyroid Gland*
- From:Journal of the Korean Ophthalmological Society
2007;48(5):630-636
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: This study was performed to evaluate the changes of tear film and ocular surface after using cyclosporine A in patients with thyroid-associated ophthalmopathy accompanied by dry eye. METHODS: Corneal sensitivity test (CST), tear break-up time (BUT), basal tear secretion test (BST), fluorescein staining (FS), tear clearance rate (TCR), and conjunctival impression cytology were evaluated in 28eyes of 28 patients with thyroid-associated ophthalmopathy accompanied by dry eye before and after using 0.1 cyclosporine A. RESULTS: CST (P=0.03), BUT (P<0.01), and BST (P=0.01) were shown significant improvements after 3 month treatment with topical 0.1% cyclosporine A. There are also shown improvments of impression cytologic findings, reduction of the degree of conjunctival squamous cell metaplasia (P=0.02) and increment of the density of goblet cell (P=0.04) after 3 month treatment. But TCR and FS were shown no significant changes after treatment. CONCLUSIONS: The improvement of parameters of tear films and ocular surface suggest the treatment with 0.1% cyclosporine A for dry eye in thyroid ophthalmopathy was effective.
