Overview of miRNA involved in PASMCs phenotypic switching in pulmonary hypertension
- Author:
Wei-Fang ZHANG
1
;
Fei XU
1
;
Ze-Ying TAO
1
;
Qian DIAO
1
;
Shan-Shan XIE
1
;
Juan LI
1
;
Rui-Lai XU
1
;
Fei XU
2
;
Ze-Ying TAO
2
;
Qian DIAO
2
;
Juan LI
3
Author Information
- Publication Type:Journal Article
- Keywords: microRNA; phenotypic switching; pulmonary artery smooth muscle cells; pulmonary hypertension; pulmonary vascular remodeling; research progress
- From: Chinese Pharmacological Bulletin 2022;38(4):506-511
- CountryChina
- Language:Chinese
- Abstract: Pulmonary hypertension ( PH) is occult, with no distinctive clinical manifestations and poor prognosis.Pulmonary vascular remodelling is an important pathological feature in which pulmonary artery smooth muscle cell ( PASMCs) pheno- typic switching plays a crucial role.MicroRNA (miRNA) is a class of evolutionary highly conserved single-stranded small non-coding RNA.Recently, an increasing number of scholars have found that miRNA can play an important role in the occurrence and development of PH by regulating the phenotypic switching of PASMCs, which is expected to be a potential target for the prevention and treatment of PH.It has been found that miR NA such as miR-221 , miR-24, miR-15b, miR-96, miR-23a.miR-9, miR-214, miR-20a can promote the phenotypic switching of PASMCs, while miRNA such as miR-21, miR-132, miR-182, miR-449, miR-206 .miR-124, miR-30c, miR-140.miR-17-92 cluster can inhibit it.This article aims to review the research progress on miRNA that mediates PASMCs phenotypic switching in PH from both growth factor-related miRNA and hy- poxia-related miRNA.
