Research progress of endoplasmic reticulum stress in methamphetamine induced neurotoxicity
- Author:
Chan WANG
1
;
Yue XU
1
;
Shu-Cheng LIN
1
;
Yi TAN
1
;
Shu-Wei ZHANG
1
;
Hui-Jie ZHANG
1
;
Xiao-Feng ZENG
1
;
Zhen LI
1
Author Information
- Publication Type:Journal Article
- Keywords: apoptosis; autophagy; endoplasmic reticulum stress; methamphetamine; neurotoxicity; unfolded protein reaction
- From: Chinese Pharmacological Bulletin 2022;38(4):501-505
- CountryChina
- Language:Chinese
- Abstract: At present, METH has surpassed the traditional illegal psychoactive substances and become the most widely abused illegal psychostimulant in China.Endoplasmic reticulum ( ER) plays an important role in regulating the normal physiological functions of various cells by virtue of its strong membrane strnc- ture and a large number of enzymes on the membrane.Endoplasmic reticulum stress ( ERS) is a series of adaptive responses made by cells when ER homeostasis is destroyed.When ERS occurs, it will drive the activation of unfolded protein response (I PR ) , which aims to protect cells from stress, reduce biosyn- thetic load and help to rebuild cell homeostasis.Persistent ERS will further aggravate the pressure of ER and induce cell death by using UPR signaling pathway.'Hie neurotoxicity induced by METH is closely related to ERS.This paper elaborates on ERS and UPR signaling pathway, and summarizes the relationship between ERS.apoptosis and autophagy, so as to provide new ideas and potential therapeutic targets for the basic research and prevention of METH induced neurotoxicity mechanism.
