Research progress of protein post-translational modification in hepatocellular carcinoma

Author: Zhuo LIU ¹ ; Pu-Hua ZENG ¹ ; Xue-Fei TIAN ²
Author Information

1. Affiliated Hospital of Hunan Academy of Traditional Chinese Medicine
2. Science and Technology Department of Hunan University of Traditional Chinese Medicine
Publication Type:Journal Article
Keywords: glycosylation; liver cancer; phosphoiylation acetylation; protein translational modifications; review
From: Chinese Pharmacological Bulletin 2022;38(6):828-831
CountryChina
Language:Chinese
Abstract: Liver cancer has the characteristics of high incidence rate, high malignancy and hidden disease.At present, the treat¬ment of liver cancer mainly includes surgery, radiotherapy and chemotherapy, but the prognosis is poor.Therefore, it is very important to explore the pathogenesis of liver cancer and find ef¬fective drugs on this basis.Protein post-translational modifica¬tion is a hot topic in epigenetics.Recent studies have found that the occurrence and development of liver cancer is related to the abnormality of post-translational modification, and can be used as a target for the diagnosis and treatment of liver cancer.This article reviews the relationship between the major protein post- translational modifications discovered in recent years and liver cancer, and provides clues for the diagnosis, treatment and prognosis of liver cancer.