Advances in research on drug-induced ovarian developmental toxicity and mechanism

Author: Jing HUANG ¹ ; Yi LIU ¹ ; Jing HUANG ² ; Ya-Wen CHEN ² ; Hui WANG ² ; Feng LYU ³
Author Information

1. Zhang Nan Hospital of Wuhan University, Dept of Obstetrics and Gynecology
2. Huhei Provincial Key Laboratory of Development Originated Diseases, Basic Medicine School of Wuhan University, Dept of Pharmacology
3. People's Hospital'of Wuhan University, Dept of Pharmacy
Publication Type:Journal Article
Keywords: drugs; neuroendocrine developmental programmin g; ovarian developmental toxicity: epigenetic modification; oxidative stress injury; pregnancy
From: Chinese Pharmacological Bulletin 2022;38(7):970-974
CountryChina
Language:Chinese
Abstract: Improper use of drugs during pregnancy ( such as en¬docrine and nervous system dnjgs) can cause fetal ovarian de¬velopmental toxicity, which induces premature ovarian failure and other related diseases susceptible in adulthood.'Hie mecha¬nism of ovarian developmental toxicity mainly involves abnormal epigenetic modification during fetal period, oxidative stress inju¬ry, intrauterine neuroendocrine development programming, etc.In this paper, the ovarian developmental toxicity and intrauterine programming mechanism of offspring induced by pregnancy med¬ication are systematically reviewed to provide evidence for the prevention and control of ovary-related diseases.