Research progress in design strategy and application of aptamers for targeted delivery of siRNA

Author: Zi-Yang LYU ¹ ; Huan-Huan HEN ¹ ; Shan WANG ¹ ; Sheng-Dan NIE ²
Author Information

1. School of Chemistry and Chemical Engineering, Central South University, Dept of Pharmaceutical Engineering
2. Office of Drug Clinical Trial Institution, Hunan Provincial Peoples Hospital
Publication Type:Journal Article
Keywords: aptamer; design strategy; gene silencing; nanocarrier; siRNA; targeted deliver)
From: Chinese Pharmacological Bulletin 2022;38(8):1141-1146
CountryChina
Language:Chinese
Abstract: RNA interference induced by small interfering (siR¬NA) has shown great potential in disease treatment.However, due to the poor stability of siRNA and lack of targeting, it is still challenging to deliver siRNA to target tissues/cells and induce gene silencing.Aptamer is a kind of oligonucleotide sequence that can specifically recognize the target.Covalently binding aptamers with siRNA or linking with other siRNA carriers can guide siRNA into target tissues/cells.In this review we summa¬ rize the research progress in the design strategy and application of aptamer-based targeted deliver)' of siRNA in the treatment of diseases in recent years, and discuss the challenges and pros-pects of aptamer-mediated siRNA deliver>r in clinical transforma¬tion.