Research progresses on correlation between connexin subcellular distribution and tumorigenesis and development
- Author:
Xiao-Cheng MO
1
;
Xiao-Ju SHEN
1
;
Xiao-Xiang MO
1
;
Fei YU
1
;
Jing-Chuan HE
1
;
Wei-Dan TAN
1
;
Zhi-Hua DENG
1
;
Zhi-Quan CHEN
1
;
Jie YANG
1
;
Zhi-Hua DENG
2
Author Information
- Publication Type:Journal Article
- Keywords: cancer; connexin; gap junction; post-translational modification; subcellular lo¬calization; therapeutic target
- From: Chinese Pharmacological Bulletin 2022;38(8):1132-1136
- CountryChina
- Language:Chinese
- Abstract: Connexin (Cx), a multigene-encoded transmembrane protein family, forms either gap junctions ( GJ) or hemichannels (HC) to mediate intercellular communication in plasma mem¬brane between adjacent cells or interacts with proteins by its car- boxyl terminal in the cytoplasm to participate in the process of tumor cell proliferation, apoptosis, necrosis, invasion, metasta¬sis, drug resistance and stem cell characteristics.However, mi- slocalization of Cx in cytoplasm or nucleus often occurs in many tumors, and involved in the occurrence and development of tumors.Subcellular localization of Cx is affected by post-transla- tional modifications, including phosphorylation, ubiquitination, and acetylation.In this paper the classification and function of Cx, the relationship between subcellular localization of Cx and tumorigenesis and the regulation of post-translational modifica¬tion on Cx are reviewed in order to provide new ideas for the study of Cx as a potential target for cancer therapy.
