Research progress of HPK1 protein kinase in tumor

Author: Lei MIAO ¹ ; Rui ZUO ¹ ; Xiao-Jun JI ¹ ; Qiu-Hua ZHOU ¹ ; Chang-You MA ¹ ; Jian WU ¹ ; Dan XU ¹
Author Information

1. Nanjing Chia Tai Tian Qing Pharmaceutical Co.ltd
Publication Type:Journal Article
Keywords: dnjg development; HPK1; kinase; signaling pathway; tumor; tumor immunology
From: Chinese Pharmacological Bulletin 2022;38(9):1292-1296
CountryChina
Language:Chinese
Abstract: Hematopoietic progenitor kinase 1 ( HPK1 ) , also known as MAP4K1 , is a serine/threonine protein kinase and a member of the MAP4K family of mammalian Ste20-related pro¬tein kinases.Recent studies have found that HPK1 is assoeiated with the occurrence and progression of a variety of tumors, and may play an important role in some malignant tumors.This pa¬ per reviews the HPK1 signaling pathway, its relationship with tumor and drug development progress, so as to provide referenee for the research of HPK1 protein kinase.