Research progress in regulating cAMP pathway to prevent and treat chronic obstructive pulmonary disease

Author: Ya-Ping LIANG ¹ ; Lue-Li WANG ¹ ; Rong HUANG ¹ ; Yan FANG ¹ ; Chen CHEN ¹ ; Chuang XIAO ¹ ; Wei-Min YANG ¹ ; Yan FANG ² ; Xiao-Hua DU ²
Author Information

1. School of Pharmaceutical Science, Yunnan Key Lab of Pharmacology for Natural Products
2. First Affiliated Hospital of Kunming Medical University, Kunming Medical University
Publication Type:Journal Article
Keywords: adenylyl cyclase; chronic obstructive pulmonary disease; cyclic adenosine monophosphate; drug development; phosphodiesterase; protein kinase A
From: Chinese Pharmacological Bulletin 2022;38(12):1773-1777
CountryChina
Language:Chinese
Abstract: Cyclic adenosine monophosphate(cAMP)is a “second messenger” that regulates cell signal transduction. Adenylyl cyclases(ACs)and phosphodiesterases(PDEs)can directly regulate cAMP level in cells and then regulate the downstream signaling pathways. Increasing intracellular cAMP level can inhibit inflammation and enhance smooth muscle relaxation, which is an effective strategy for the prevention and treatment of chronic obstructive pulmonary disease(COPD). This paper briefly summarizes the signaling pathways regulating cAMP and their mechanisms and related drugs in COPD therapy, hoping to provide references for further research and development of new target drugs which regulate cAMP for the prevention and treatment of COPD.