Neurovascular coupling and central nervous system diseases

Ju-xiang Yang; Gang LI; Nai-hong Chen; Zhao Zhang; Shi-feng Chu; Nai-hong Chen; Zhao Zhang; Wen-bin HE; Nai-hong Chen

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Neurovascular coupling and central nervous system diseases

Author: Ju-Xiang YANG ¹ ; Gang LI ¹ ; Nai-Hong CHEN ¹ ; Zhao ZHANG ² ; Shi-Feng CHU ² ; Nai-Hong CHEN ² ; Zhao ZHANG ³ ; Wen-Bin HE ³ ; Nai-Hong CHEN ³
Author Information

1. College of Pharmacy, Inner Mongolia Medical University
2. State Key Laboratory of Bioactive Substances and Functions of Natural Medicine, Neuroscience Center, Institute of Materia Medica, Chinese Academy of Medical Sciences
3. Shanxi Key Laboratory of Chinese Medicine Encephalopathy, Shanxi University of Chinese Medicine
Publication Type:Journal Article
Keywords: active substance; central nervous system diseases; neurovascular coupling; neurovascular units; regulatory mechanism; research methods
From: Chinese Pharmacological Bulletin 2023;39(12):2225-2230
CountryChina
Language:Chinese
Abstract: Neurovascular coupling is the function of regulating blood flow of the central nervous system at the level of neurovascular units. The central nervous system diseases related to neurovascular coupling mainly include cerebrovascular diseases such as chronic cerebral ischemia and neurodegenerative diseases such as Alzheimer's disease,Parkinson's disease and Lewy body dementia. The main mechanism of neurovascular coupling dysfunction leading to the above diseases is cerebrovascular dysfunction or loss,which leads to serious damage to neuronal ischemia and affects its function. Therefore,this paper reviews the research status of neurovascular coupling and its related central nervous system diseases,in order to guide the follow-up research. The purpose of this paper is to provide a basis for the prevention,relief and treatment of central nervous system diseases related to neurovascular coupling through the mechanism of neurovascular coupling.