Advances in cGAS-STING pathway and its inhibitors in immune and inflammatory diseases

Author: Wen-Xin LI ¹ ; He-Feng ZHANG ¹ ; Zuo-Quan XIE ¹ ; Wen-Hu DUAN ¹
Author Information

1. Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Publication Type:Journal Article
Keywords: cyclic dinucleotide; cyclic GMP-AMP synthase; immune diseases; inhibitors; stimulator of interferon genes; type I interferon
From: Chinese Pharmacological Bulletin 2023;39(11):2001-2005
CountryChina
Language:Chinese
Abstract: The cGAS-STING signaling pathway is one of the main pathways of immune defense against many types of pathogens. cGAS catalyzes the production of the second messenger cGAMP (cyclic GMP-tVMP) by recognizing plasma DNA and cGAMP subsequently binds to the interferon gene stimulating factor (STING). The pathway induces the production of type I interferon (IFN-I) and activates the innate immune system. The activation of the cGAS-STI]NG pathway could facilitate self-protection,thus STI]NG agonists for tumor immunotherapy have attracted much attention in recent years,and several drug candidates have been in clinical trials. Meanwhile,aberrant activation of cGAS-STI]NG could lead to autoimmune diseases and has attracted extensive interest in developing its inhibitors. This paper summarizes the mechanism and regulatory sites of the cGAS-STI]NG pathway,and outlines the research progress of cGAS-STING pathway-related immune and inflammatory diseases and its inhibitors.