Chinese Traditional Medicine Jiangtang Wan ameliorates kidney injury and fîbrosis in mice with diabetic kidney disease via inhibiting TGF-pj

Author: Yu-Qing REN ¹ ; Tang TANG ¹ ; Ying-Ling DUAN ¹ ; Ning LI ¹ ; Hui FAN ¹ ; Tian LAN ¹ ; Ying LI ² ; Rui-Xin DAI ³
Author Information

1. Institute of Chinese Medicine, Guangdong Pharmaceutical University, Guangdong Metabolic Diseuses Research Center of Integrated Chinese and Western Medicine, Key Lahoratory of Glucolipid Metabolic Disorder, Ministry of Education, Guangdong TCM Key Lahoratory for Metabolic Diseuses
2. School of Pharmacy, Guangdong Pharmaceutical University
3. Dai Ruixin Clinic of Traditional Chinese Medicine
Publication Type:Journal Article
Keywords: diabetic kidney disease; fibronectin; interstitial fibrosis; Jiangtang Wan; kidney injury; transforming growth factor-β
From: Chinese Pharmacological Bulletin 2023;39(10):1988-1993
CountryChina
Language:Chinese
Abstract: Aim To investigate the therapeutic effect of Jiangtang Wan (JTW) on mioe with diabetic kidney disease (DKD) and to explore its potential moiecuiar mechanism on ameliorating renal injury and fibrosis. Methods C57BL/6 mice were randomly divided into four groups: the control group, the model group, JTW group (1250 mg • kg