Regulation of Dracocephalum Moldavica total flavonoids on foaming and inflammatory response of RAW264. 7 maerophages
- Author:
Chun-Yan DU
1
;
Xu-Li RUAN
1
;
Yun-Li ZHAO
2
;
Xin-Chun WANG
2
;
Wen-Jiang CAO
2
Author Information
- Publication Type:Journal Article
- Keywords: atherosclerosis; Dracocephalum Moldavica total flavonoids; foam cells; inflammatory response; maerophages; NF-KB
- From: Chinese Pharmacological Bulletin 2023;39(10):1973-1979
- CountryChina
- Language:Chinese
- Abstract: Aim To investigate the effeets of Dracocephalum Moldavica total flavonoids (TFDM) on the foaming lipoprotein (ox-LDL), and to further elucidate the mechanism of anti-atherosclerosis (AS) of TFDM. Methods RAW264. 7 maerophages were cultured in vitro and induced to become foam cells by ox-LDL stimulation, and inflammation of mouse monocyte macrophage leukemia cells (RAW264. 7) induced by oxi-dized low density TFDM(25, 50, 100 mg • L"