Study on protective effect of Shenqi Fuzheng injection on immune myocarditis injury induced by anti-PD-1 antibody

Author: Qian LIU ¹ ; Wen-Cong GAO ¹ ; Xin MA ¹ ; Chang-Bo ZHENG ¹ ; Jia-Ming YANG ² ; Hai-Bin HUANG ² ; Zhen-Xiang HU ²
Author Information

1. School of Pharmaceutical Science, Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University
2. Lizhu Monoclonal Antibody Biotechnology Limited Liability Company
Publication Type:Journal Article
Keywords: anti PD-1 antibody; cardiotoxicity; experimental autoimmune myocarditis model; inflammatory response; myocardial injury; Shenqi Fuzheng injection
From: Chinese Pharmacological Bulletin 2023;39(10):1980-1987
CountryChina
Language:Chinese
Abstract: Aim To investigate the effeot of Shenqi Fuzheng injection on the prevention of immune myocarditis induced by anti-PD-1 antibody by reducing the production of inflammatory factors and the expression of myocardial injury markers. Methods Thirty-two maie PD-1 humanized mice with C57BL/6 genetic background were randomly divided into control group, myocarditis model group, anti-PD-1 antibody group and Shenqi Fuzheng injection group (n = 8). Except the control group, mice in other groups were intraperitoneally injected with myocardial myosin heavy chain peptide (5 mg • kg