Treatment advice of small molecule antiviral drugs for elderly COVID-19

Min Pan; Shuang Chang; Xiao-xia Feng; Guang-he Fei; Jia-bin LI; Hua Wang; Du-juan XU; Chang-hui Wang; Yan Sun; Xiao-yun Fan; Tian-jing Zhang; Wei Wei; Ling-ling Zhang; Jim LI; Fei-hu Chen; Xiao-ming Meng; Hong-mei Zhao; Min Dai; Yi Xiang; Meng-shu Cao; Xiao-yang Chen; Xian-wei YE; Xiao-wen HU; Ling Jiang; Yong-zhong Wang; Hao Liu; Hai-tang Xie; Ping Fang; Zhen-dong Qian; Chao Tang; Gang Yang; Xiao-bao Teng; Chao-xia Qian; Guo-zheng Ding

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Treatment advice of small molecule antiviral drugs for elderly COVID-19

Author: Min PAN ¹ ; Shuang CHANG ¹ ; Xiao-Xia FENG ¹ ; Guang-He FEI ¹ ; Jia-Bin LI ¹ ; Hua WANG ¹ ; Du-Juan XU ¹ ; Chang-Hui WANG ¹ ; Yan SUN ¹ ; Xiao-Yun FAN ¹ ; Tian-Jing ZHANG ² ; Wei WEI ² ; Ling-Ling ZHANG ² ; Jim LI ³ ; Fei-Hu CHEN ³ ; Xiao-Ming MENG ³ ; Hong-Mei ZHAO ⁴ ; Min DAI ⁵ ; Yi XIANG ⁶ ; Meng-Shu CAO ⁷ ; Xiao-Yang CHEN ⁸ ; Xian-Wei YE ⁹ ; Xiao-Wen HU ¹⁰ ; Ling JIANG ¹⁰ ; Yong-Zhong WANG ¹¹ ; Hao LIU ¹² ; Hai-Tang XIE ¹³ ; Ping FANG ¹⁴ ; Zhen-Dong QIAN ¹⁵ ; Chao TANG ¹⁶ ; Gang YANG ¹⁷ ; Xiao-Bao TENG ¹⁸ ; Chao-Xia QIAN ¹⁹ ; Guo-Zheng DING ²⁰
Author Information

1. The First Affiliated Hospital of Anhui Medical University
2. Institute of Clinical Pharmacology, Anhui Medical University
3. College of Pharmacy, Anhui Medical University
4. China-Japan Friendship Hospital
5. Anhui University of Chinese Medicine
6. Ruijin Hospital, School of Medicine, Shanghai Jiaotong University
7. Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School
8. The Second Affiliated Hospital, Fujian Medical University
9. Guizhou Provincial People' s Hospital
10. The First Affiliated Hospital of University of Science and Technology of China
11. The First Affiliated Hospital, Anhui University of Chinese Medicine
12. College of Pharmacy, Bengbu Medical College
13. The First Affiliated Hospital of Wannan Medical College
14. Tongling People' s Hospital
15. Tongling Municipal Hospital
16. Bozhou Hospital of Traditional Chinese Medicine
17. The Second People' s Hospital of Wuhu
18. The Second People' s Hospital of Fuyang
19. Bengbu Third People' s Hospital Affiliated to Bengbu Medical College
20. Anqing Municipal Hospital
Publication Type:Journal Article
Keywords: antiviral drugs; clinical rational use; COVID-19; drug interactions; the elderly; treatment advice
From: Chinese Pharmacological Bulletin 2023;39(3):425-430
CountryChina
Language:Chinese
Abstract: COVID-19 has been prevalent for three years. The virulence of SARS-CoV-2 is weaken as it mutates continuously. However, elderly patients, especially those with underlying diseases, are still at high risk of developing severe infections. With the continuous study of the molecular structure and pathogenic mechanism of SARS-CoV-2, antiviral drugs for COVID-19 have been successively marketed, and these anti-SARS-CoV-2 drugs can effectively reduce the severe rate and mortality of elderly patients. This article reviews the mechanism, clinical medication regimens, drug interactions and adverse reactions of five small molecule antiviral drugs currently approved for marketing in China, so as to provide advice for the clinical rational use of anti-SARS-CoV-2 in the elderly.