Effects of SIRT1 on morphine-induced conditioned place preference in rats through CREB/BDNF pathway
- Author:
Ben LIU
1
;
Wan-Yu TU
1
;
Teng-Teng ZHANG
1
;
Shan-Yong YI
1
;
Guo-Sheng LUO
1
;
Wen-Ge JIA
1
;
Chen-Chen LI
1
;
Bin ZHAO
1
;
Lai WEI
1
;
Zhi-Jun YAO
2
;
Ying ZHAO
3
Author Information
- Publication Type:Journal Article
- Keywords: addiction; conditioned place preference; EX527; morphine; SIRT1; ventrolateral orbital cortex
- From: Chinese Pharmacological Bulletin 2023;39(7):1263-1270
- CountryChina
- Language:Chinese
- Abstract: Aim To investigate the effect of microinjection of EX527, a selective SIRT1 antagonist, into the ventrolateral orbital cortex (VLO) on morphine-induced conditioned place preference (CPP), and to explore the role of CREB/BDNF in it. Methods The cannulas were implanted bilaterally in the VLO of rats by brain stereotaxis surgery, and the model of morphine-induced CPP was established. The behavioral experiment consisted of four stages:habituation (d 1), pre-test (d 2-4), conditioning training (d 5-14) and test (d 15). At the stage of conditioning training, EX527 (1 μL, 5 g·L
