Review of constructing animal models of depression after myocardial infarction

Author: Yi-Ze SUN ¹ ; Zhe-Yi WANG ¹ ; Yi-Ze SUN ² ; Jin-Yu SHI ³ ; Xin QI ³ ; Jun-Ling CAO ³
Author Information

1. Qilu Hospital (Qingdao), Shandong University
2. The Third Affiliated Hospital of Beijing University of Chinese Medicine
3. Oriental Hospital, Beijing University of Chinese Medicine
Publication Type:Journal Article
Keywords: animal models; behavior test; complex model; depression after myocardial infarction; environmental stress; review
From: Chinese Pharmacological Bulletin 2023;39(3):401-406
CountryChina
Language:Chinese
Abstract: The incidence of depression after myocardial infarction (DAMI) is high, causing significant harm to the patients' physical and mental health, but the pathogenesis is unknown. Establishing animal models which simulate the pathogenesis of DAMI in humans is an effective way to explore the mechanism of the disease. In this paper, problems existing in the modeling process, such as animal selection, model selection, model preparation and behavioral evaluation, are summarized and considered in order to provide reference for DAMI model research.