Effect of Lulong Zaisheng Decoction II on chemotherapy-induced bone marrow suppression and its mechanism

Author: Fei PENG ¹ ; Ting-Ting QIN ¹ ; Can-Hong HU ¹ ; Zhao-Jing YU ¹ ; Zhi-Jun FANG ¹ ; Fei PENG ² ; Ting-Ting QIN ² ; Can-Hong HU ² ; Zhi-Jun FANG ² ; Zhao-Jing YU ³ ; Jian-Hua ZHU ³ ; Jian-Hua ZHU ⁴ ; Wei-Wei CUI
Author Information

1. Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine
2. Jiangsu Province Academy of Traditional Chinese Medicine
3. Liang-chun Guoyitang of Nantong
4. Affiliated Hospital of Nantong University
Publication Type:Journal Article
Keywords: apoplosis; cell cycle; chemotherapy; colorectal cancer; Lulong Zaisheng Decoction II; myelosuppression
From: Chinese Pharmacological Bulletin 2023;39(5):986-993
CountryChina
Language:Chinese
Abstract: Aim To investigate the effect of Lulong Zaisheng Decoction II on chemotherapy-induced bone marrow suppression in nude mice bearing colorectal cancer. Methods Male BALB/C nude mice were inoculated with human colon cancer cell HT-29 under the armpit. The tumor bearing nude mice were randomly divided into five groups: control group, chemotherapy group, positive drug group, Lulong Zaisheng Decoction II groups with high and low doses. The mice were given drugs by gavage once a day for 10 consecutive days. From the fourth day of the experiment, except for the control group, the nude mice were intraperitoneally injected with 5-FU at dose of 25 mg • kg