- Author:
Chen-Guang LI
1
;
Jing-Rong LIANG
1
;
Li-Zu XIAO
1
;
Zhi-Guo ZHANG
1
;
Chen-Guang LI
2
;
Jing-Rong LIANG
2
;
Li-Zu XIAO
2
;
Feng-Yi MAI
3
Author Information
- Publication Type:Journal Article
- Keywords: Gasdermin D; Gasdermin family; inflammation; inflammsome; pyroptosis
- From: Chinese Pharmacological Bulletin 2023;39(5):817-822
- CountryChina
- Language:Chinese
- Abstract: Pyroptosis is a novel process of programmed inflammatory necrosis, which is closely related to microbial infections and autoimmune diseases. In recent years it has been proved that Gasdermin D is an executive protein of pyroptosis. Cleaved Gasdermin D leads to the formation of pores in cell membrane to induce pyroptosis, and the release of inflammatory factors such as IL-1β and IL-18 aggravates the occurrence of inflammatory responses. With the deepening of Gasdermin D research, it is gradually clear its protein structure and activation sites, which has other activation pathways apart from inducing inflammasome activation. Activation of Gasdermin D does not necessarily mean cell death, even if it could induce the formation of pores in cell membrane and regulation of inflammatory cytokine secretion. These findings offer insight into Gasdermin D function and change our understanding of pyroptosis and programmed necrosis. The recent progress of Gasdermin D is highlighted in this review.