Calpain-1 accelerates endothelial cell apoptosis in pulmonary hypertension by inducing endoplasmic reticulum stress
- Author:
He-Ning SUN
1
;
Mei-Li LU
1
;
Xiao-Xue TIAN
1
;
Hai-Yan DENG
1
;
Huan LIU
1
;
Hong-Xin WANG
1
Author Information
- Publication Type:Journal Article
- Keywords: apoptosis; calpain-1; endoplasmic reticulum stress; hypoxia; pulmonary artery endothelial cells; pulmonary hypertension
- From: Chinese Pharmacological Bulletin 2023;39(4):723-730
- CountryChina
- Language:Chinese
- Abstract: Aim To explore the mechanism by which calpain-1 promotes hypoxia-induced pulmonary hypertension pulmonary artery endothelial cell apoptosis through endoplasmic reticulum stress. Methods C57BL/6 wild-type (WT) and calpain-1 gene knockout mice (KO) were reared in a hypoxic chamber (10% O
