Effect of a novel phosphodiesterase type 5 inhibitor, CPD1, on paraquat-induced lung fibrosis in rats

Author: Jie GAO ¹ ; Jian WU ¹ ; Jie GAO ² ; Jing ZHANG ² ; Jian WU ² ; Jian-Qin YANG ³ ; Hao-Heng QIU ³ ; Zi-Jian ZHAO ³ ; Fang-Hong LI ³ ; Yun-Ping MU ³
Author Information

1. The Second School of Clinical Medicine, Southern Medical University, Guangdong Academy of Medical Sciences, Guangdong Provincial Geriatrics Institute
2. Second Dept of Elderly Respiratory Diseases, Guangdong Provincial People′s Hospital, Guangdong Academy of Medical Sciences, Guangdong Provincial Geriatrics Institute
3. School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology
Publication Type:Journal Article
Keywords: alveolar epithelial cells; CPD1; epithelial-mesenchymal transition; lung fibrosis; paraquat; phosphodiesterase type 5 inhibitors
From: Chinese Pharmacological Bulletin 2023;39(6):1136-1142
CountryChina
Language:Chinese
Abstract: Aim To investigate the effects of CPD1, a novel phosphodiesterase 5 inhibitor, on lung pathological phenotype and epithelial-mesenchymal transition of alveolar epithelial cells in lung fibrosis model rats caused by paraquat (PQ). Methods Lung fibrosis model was constructed by a single intraperitoneal injection of PQ (30 mg·kg