Study on "Spectrum-material-effect" relationship of Compound Muji Granules against liver tumor based on microfluidic chip
- Author:
Yan QIN
1
;
Yong-Rui BAO
1
;
Shuai WANG
1
;
Tian-Jiao LI
1
;
Xian-Sheng MENG
1
;
Yong-Rui BAO
2
;
Shuai WANG
2
;
Tian-Jiao LI
2
;
Xian-Sheng MENG
2
;
Xiu-Jun ZHANG
3
;
Hai-Ou PAN
4
Author Information
- Publication Type:Journal Article
- Keywords: Compound Muji Granules; fingerprint; liver tumor; material basis; microfluidic chip; spectral analysis
- From: Chinese Pharmacological Bulletin 2023;39(1):185-192
- CountryChina
- Language:Chinese
- Abstract: Aim To explore the material basis of anti-tumor effect of Compound Muji Granules. Methods The anti-tumor pharmacodynamics of Compound Muji Granules in vitro was studied by microfluidic chip technology. The fingerprint of Compound Muji Granules was established by HPLC. The "Spectrum-Material-Effect" of Compound Muji Granules was analyzed by grey correlation analysis,partial least squares regression analysis and network pharmacology approach. Results Seven batches of Compound Muji Granules with different extraction methods were successfully established. The results of grey correlation analysis showed that there was a positive correlation between Compound Muji Granules and 7 of the 14 components with pharmacodynamic correlation coefficient >0.80. The contribution of anti liver tumor was peak number 48(luteolin)>6(gallic acid)>19(chlorogenic acid)>59(quercetin)>67(kaempferol)>65(naringin)>38(ellagic acid),in that order. Conclusions Through the establishment of "Spectrum-Material-Effect" research method,it is clear that the above seven active monomers may be the anti-tumor material basis of Compound Muji Granules.
