HDAC3-a key target for preventing organ ischemia-reperfusion injury

Author: Ming-Lang GAO ¹ ; Kai LAI ¹ ; Ting-Lyu FU ¹ ; Ning LI ¹ ; Qing GENG ¹
Author Information

1. Dept of Thoracic Surgery, Renmin Hospital of Wuhan University
Publication Type:Journal Article
Keywords: HDAC3; histone; ischemia-reperfusion injury; organ; prevention; shock
From: Chinese Pharmacological Bulletin 2023;39(1):9-13
CountryChina
Language:Chinese
Abstract: Histone deacetylase 3 (HDAC3) plays an important role in chromatin remodeling, which in turn regulates gene transcription, so HDAC3 is involved in the pathophysiology of various diseases through epigenetic regulation. Organ ischemia-reperfusion injury (I R I) is a pathophysiological process that leads to the development of a variety of diseases such as delayed neuronal necrosis, irreversible shock, myocardial infarction, acute organ failure and organ transplant rejection. In this paper we review the pathophysiological function of HDAC3 and its role in the development of IRI in human parenchymal organs, and also explore the therapeutic value of HDAC3 in IRI.