Study on processing and enhance the curative effects of Arisaematis rhizomz preparatum based on network pharmacology

Xu WU; Jing Wang; Ting Zou; Ya-nan WU; Si-hua Wen; Xi Chen; Su-rong HE; Chun-yan QI; Qian Liu; Ya-juan LI; Qiao Zhang; Chong-bo Zhao; Xu WU; Jing Wang; Ting Zou; Ya-nan WU; Su-rong HE; Chun-yan QI; Qiao Zhang; Chong-bo Zhao; Xu WU; Jing Wang; Ting Zou; Ya-nan WU; Qiao Zhang; Chong-bo Zhao; Jing Nian

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Study on processing and enhance the curative effects of Arisaematis rhizomz preparatum based on network pharmacology

Author: Xu WU ¹ ; Jing WANG ¹ ; Ting ZOU ¹ ; Ya-Nan WU ¹ ; Si-Hua WEN ¹ ; Xi CHEN ¹ ; Su-Rong HE ¹ ; Chun-Yan QI ¹ ; Qian LIU ¹ ; Ya-Juan LI ¹ ; Qiao ZHANG ¹ ; Chong-Bo ZHAO ¹ ; Xu WU ² ; Jing WANG ² ; Ting ZOU ² ; Ya-Nan WU ² ; Su-Rong HE ² ; Chun-Yan QI ² ; Qiao ZHANG ² ; Chong-Bo ZHAO ² ; Xu WU ³ ; Jing WANG ³ ; Ting ZOU ³ ; Ya-Nan WU ³ ; Qiao ZHANG ³ ; Chong-Bo ZHAO ³ ; Jing NIAN ⁴
Author Information

1. College of Pharmacy, Shaanxi University of Chinese Medicine
2. Engineering Technology Research Center of Shaanxi Administration of Chinese Herbal Pieces
3. Shaanxi Traditional Chinese Medicine Processing Technology Heritage Base
4. The Second Affiliated Hospital of Shaanxi University of Chinese Medicine, Dept of Pharmacy
Publication Type:Journal Article
Keywords: allergic asthma; Arisaematis rhizomz preparatum; composition change; network pharmacology; processing to enhance curative effect; UPLC-Q-TOF-MS/MS
From: Chinese Pharmacological Bulletin 2023;39(2):357-366
CountryChina
Language:Chinese
Abstract: Aim To explore the mechanism of process¬ing and increasing efficiency of Arisaematis rhizomz preparatum. Methods UPLC-Q-TOF-MS/MS tech¬nology was used to detect the chemical components be¬fore and after processing of Arisaematis rhizomz prepara¬tum, and its mechanism of action was analysed in the treatment of 44 asthma and phlegm " by using network pharmacology. A rat model of allergic asthma was es- tablished to compare the efficacy of Arisaematis rliizoma before and after processing. Results A total of 27 chemical components were identified, among which cur- cumin ,6-gingerol and other components increased after processing. Combined with the database prediction, the action mechanism of the 36 chemical components in the treatment of 44 asthma and phlegm" diseases was dis¬cussed and predicted through network pharmacology. The results of animal experiments showed that the effect of processed Arisaematis rhizoma on allergic asth¬ma was better than that of Arisaematis rhizoma, but there was no significant difference. Conclusions The addition of curcumin, 6-gingerol, camphor, demethyl- curcumin and other components after the processed Ari¬saematis rhizomz preparatum may be the reason for the synergistic effect of Arisaematis rhizomz preparatum in the treatment of allergic asthma.