Pharmacokinetics and blood-brain barrier penetration of a novel salidroside derivative pOBz in rats
- Author:
Rui LUO
1
;
Gui-Zhu HONG
1
;
Jing-Wen NIE
1
;
Si-Ying HUANG
1
;
Zheng-Shuang YU
1
;
Bin-Bin ZHOU
1
;
Wen-Fang LAI
1
;
Ze-Lin YANG
1
Author Information
- Publication Type:Journal Article
- Keywords: blood-brain barrier; elimination half-life; pharmacokinetics; pOBz; salidroside derivative; UPLC-MS/MS
- From: Chinese Pharmacological Bulletin 2023;39(3):543-548
- CountryChina
- Language:Chinese
- Abstract: Aim To develop a ultra-high performance liquid chromatography electrospray-ionization tandem mass spectrometry ( UPLC-MS/MS ) method for the simultaneous determination of salidroside derivative pOBz in rat plasma and brain tissue, and to study the pharmacokinetic profile and penetration of the blood-brain barrier in rats after a single dose intravenous administration of pOBz. Methods SD rats were administered pOBz at a dose of 50 mg • kg
