Effect and mechanism of p-hydroxybenzaldehyde on experimental intestinal fibrosis
- Author:
Xi LU
1
;
Yi-Han MA
1
;
Bing QIN
1
;
Yu-Hui WANG
1
;
Xiao-Tian XU
1
;
Xiao-Qun DUAN
2
;
Xiao-Qun DUAN
3
Author Information
- Publication Type:Journal Article
- Keywords: cadherin-switch; collagen deposition; epithelial-mesenchymal transition; inflammatory bowel disease; intestinal fibrosis; p-hydroxy benzaldehyde
- From: Chinese Pharmacological Bulletin 2023;39(4):685-692
- CountryChina
- Language:Chinese
- Abstract: Aim To investigate the effect of p-hydroxybenzaldehyde ( HD) on intestinal fibrosis in mice based on mouse intestinal fibrosis model and in vitro EMT model,and to explore the underlying mechanism Methods HE staining, Masson staining, immunohisto-chemistry ,qPCR, Western blot and other experimental methods were used to verify the effect of HD on intestinal fibrosis in mice and the potential mechanism. Results In vivo experiments showed that compared with the normal group, the DSS-induced intestinal fibrosis model group had shortened colon, increased colon his-topathological score, increased collagen volume fraction, and significantly increased collagen I expression. After treatment with 4, 10, and 25 mg • kg
