Artesunate inhibits development of esophageal squamous cell carcinoma via regulating expression of Skp2 and P21

Author: Min ZHANG ¹ ; Li-Ting SUN ¹ ; Guan-Tong SHEN ¹ ; Ru-Yi SHI ¹ ; Min ZHANG ² ; Ru-Yi SHI ² ; Nan QIN ³ ; Xiao-Ling HU ⁴ ; Jie YANG ⁵ ; Yong-Hua ZHANG ⁶
Author Information

1. Dept of Medical Cell Biology and Genetics, Shanxi Medical University
2. Translational Medicine Research Center, Shanxi Medical University
3. College of Pharmaceutical and Food Engineering, Shanxi University of Chinese Medicine
4. Dept of Pharmacology, Shanxi Medical University
5. Dept of Gastroenterology, Second Hospital, Shanxi Medical University
6. Jiancaoping District Center for Disease Control and Prevention
Publication Type:Journal Article
Keywords: Artesunate; cell cycle; cell invasion; cell migration; cell proliferation; Chinese patent medicine; esophageal squamous cell carcinoma
From: Chinese Pharmacological Bulletin 2023;39(5):844-850
CountryChina
Language:Chinese
Abstract: Aim To clarify the regulatory effect of Artesunate(ART) on tumor cell function and cell cycle in the pathological process of esophageal squamous cell carcinoma(ESCC). Methods KYSE450 and TE14 cells were treated with different concentrations of ART. The cells treated with 0 mg •L