Effect of NMDA receptor blocker in relieving HIV-1/gp120 induced learning and memory disorder in rats and its mechanism
- Author:
Mei LIANG
1
;
Jia-Jia YU
1
;
Xi-Yong XIANG
1
;
Si-Yu XIA
1
;
Shan LI
1
;
Yi-Rong ZENG
1
;
Li-Xuan WANG
1
;
Yi-Un ZHOU
1
;
Yan ZHOU
1
;
Shan LI
2
;
Yan ZHOU
3
Author Information
- Publication Type:Journal Article
- Keywords: apoptosis; endoplasmic reticulum stress; gpl20; inflammation; learning and memory disorders; NMDA receptors
- From: Chinese Pharmacological Bulletin 2023;39(6):1149-1156
- CountryChina
- Language:Chinese
- Abstract: Aim: To investigate the alleviating effect of NMDA receptor blocking on learning and memory impairment induced by gp120 in rats and its mechanism. Methods: (1 ) Thirty-two SD rats were randomly divided into control group, sham operation group, gpl20 group, and gp120 + Memantine group. Except for the control group, the other groups underwent a bilateral hippocampal injection to establish the model of learning and memory impairment in rats. Memantine (10 mg • kg
