Artemisia argyi attenuates airway inflammation in lipopolysaccharide induced acute lung injury model.
10.5625/lar.2017.33.3.209
- Author:
Na Rae SHIN
1
;
Sung Hyeuk PARK
;
Je Won KO
;
Hyung Won RYU
;
Seong Hun JEONG
;
Jong Choon KIM
;
Dong Ho SHIN
;
Hoon Sang LEE
;
In Sik SHIN
Author Information
1. College of Veterinary Medicine (BK21 project team), Chonnam National University, Gwangju, Korea. dvmmk79@gmail.com
- Publication Type:Original Article
- Keywords:
Artemisia argyi;
dehydromatricarin A;
acute lung injury;
inducible nitric oxide synthase;
nuclear factor kappa B
- MeSH:
Acute Lung Injury*;
Animals;
Artemisia*;
Bronchoalveolar Lavage Fluid;
Inflammation*;
Interleukins;
Korea;
Lung;
Mice;
NF-kappa B;
Nitric Oxide Synthase Type II;
Phosphorylation;
Tea;
Tumor Necrosis Factor-alpha
- From:Laboratory Animal Research
2017;33(3):209-215
- CountryRepublic of Korea
- Language:English
-
Abstract:
Artemisia argyi is used as a health supplement, tea, and food source in Korea. This study aimed to evaluate the effect of Artemisia argyi (AA) and its active compound, dehydromatricarin A (DA), on the attenuation of airway inflammation in a murine model of lipopolysaccharide (LPS)-induced acute lung injury (ALI). The C57BL/6 mice were administered AA (50 mg/kg or 100 mg/kg) and DA (10 mg/kg or 20 mg/kg) by oral gavage from day 0 to 7 days and LPS treated by intranasal instillation 48 hours before the sacrifice. The treatment of AA and DA markedly decreased inflammatory cells in the bronchoalveolar lavage fluid (BALF) compared with that in ALI-induced mice, which was accompanied by a significant reduction in the levels of tumor necrosis factor (TNF)-α and interleukin (IL)-6 in BALF. Furthermore, the administration of AA and DA clearly decreased inducible nitric oxide synthase (iNOS) expression and nuclear factor kappa B (NF-κB) phosphorylation in comparison with that in the ALI-induced mice. The histological examination of the lung tissue revealed that the administration of AA and DA suppressed the inflammatory cell infiltration into the peribronchial and alveolar lesions induced by LPS instillation. Collectively, our results indicated that AA and DA effectively decreased the airway inflammatory response induced by LPS instillation. Therefore, AA and DA may offer a potential therapy for airway inflammatory disease.
