Irisin inhibits myocardial injury induced by cobalt dichloride through regulating Sirtl/UCP2 pathway
- Author:
Ru-Li LI
1
;
Yun-Xiao HUANG
1
;
Bin HAN
1
;
Fu LIU
1
;
Ru-Li LI
2
;
Bin HAN
2
;
Fu LIU
2
;
Yun-Xiao HUANG
3
Author Information
- Publication Type:Journal Article
- Keywords: apoptosis; Irisin; mitochondrial membrane potential; oxidative stress; Sirtl; UCP2
- From: Chinese Pharmacological Bulletin 2023;39(6):1061-1066
- CountryChina
- Language:Chinese
- Abstract: Aim To investigate the role and specific mechanisms of muscle factor Irisin in regulating the intracellular protective protein Sirtl and mitochondrial uncoupling protein 2 (UCP2) during myocardial hypoxia. Methods H9c2 cells were treated with CoC12 for 24 hours to construct an in vitro hypoxia model of myocardial cells. Six groups were divided in this experiment; control group (control), Irisin group (10 nmol • L
