Myocardial specific overexpression of Sirt1 inhibits recovery of cardiac function in mice with myocardial ischemia

Author: Tian-Tian LIU ¹ ; Jun-Ling CAO ¹ ; Qing-Qing WANG ² ; Jin-Long DUAN ² ; Jian-Guo LIN ² ; Kui-Wu YAO ² ; Kui-Wu YAO ³
Author Information

1. Dongfang Hospital, Beijing University of Chinese Medicine
2. Guang'anmen Hospital, China Academy of Chinese Medical Sciences
3. Eye Hospital, China Academy of Chinese Medical Sciences
Publication Type:Journal Article
Keywords: angiogenesis; cardiac dysfunction; cardiomyocyte apoptosis; myocardial ischemia; silent information regulator 1; Sirtl overexpression transgenic mice
From: Chinese Pharmacological Bulletin 2023;39(6):1036-1041
CountryChina
Language:Chinese
Abstract: Aim To investigate the effect of overexpression of silent information regulator 1 (Sirtl) on cardiac function in mice with myocardial ischemia. Methods Myocardial specific Sirtl overexpression transgenic mice (Sirtl-Tg) and littermate control mice (C57BL/6J), half male and half female, were randomly divided into control sham operation group (Con), control model group (Con +ISO), Sirtl overexpression sham operation group (Sirtl-Tg) and Sirtl overexpression model group (Sirtl-Tg + ISO). Isoproterenol (ISO) was injected subcutaneously into the back of the neck at 100 mg • kg