Research on mechanism of opioid receptors in pharmacological effects of ketamine

Ya-Nan QIU; Feng-Hua FU; Ya-Nan QIU; Yi SUN; Rui-Bin SU

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Research on mechanism of opioid receptors in pharmacological effects of ketamine

Author: Ya-Nan QIU ¹ ; Feng-Hua FU ¹ ; Ya-Nan QIU ² ; Yi SUN ² ; Rui-Bin SU ²
Author Information

1. School of Pharmacy, Yantai University
2. State Key Laboratory of Toxicology and Medical Countermeasures, Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences
Publication Type:Journal Article
Keywords: addiction; analgesia; anesthesia; anti-addiction; anti-depression; ketamine; opioid receptor
From: Chinese Pharmacological Bulletin 2023;39(6):1019-1022
CountryChina
Language:Chinese
Abstract: Ketamine has been used clinically as an analgesic and anesthetic since 1970. Recently, it has been concerned due to its rapid and effective antidepressant effect. However, the psychiatric adverse reactions caused by ketamine such as addiction and hallucination limit its clinical application, yet the mechanism of the adverse reactions is still unclear. At present, it is generally believed that the pharmacological effects of ketamine are mainly mediated by N-methyl-D-aspartate acid (NMDA) receptors, but increasing numbers of research evidences suggest that the opioid receptor also play an important role in the pharmacological effects of ketamine. This review, based on the relevant literature published publicly in the past 20 years, summarizes the mechanisms of opioid receptors in the pharmacological effects of ketamine, such as anesthesia, analgesia, anti-depressant, anti-addiction and addiction, providing reference for revealing the mechanism of ketamine, and making beneficial exploration for solving the clinical side effects of ketamine.