Research progress of endothelial-mesenchymal transdifferentiation in fibrotic diseases

Yi Liu; Zhen LI; Yuan-jie Hao; Zhen-hua Jia; Yi Liu; Zhen LI; Ya-fen Wang; Yuan-jie Hao; Zhen-hua Jia; Yu-jie Yin; Zhen-hua Jia; Yu-jie Yin; Zhen-hua Jia; Yu-jie Yin; Zhen-hua Jia; Ya-fen Wang; Zhen-hua Jia

Return

Research progress of endothelial-mesenchymal transdifferentiation in fibrotic diseases

Author: Yi LIU ¹ ; Zhen LI ¹ ; Yuan-Jie HAO ¹ ; Zhen-Hua JIA ¹ ; Yi LIU ² ; Zhen LI ² ; Ya-Fen WANG ² ; Yuan-Jie HAO ² ; Zhen-Hua JIA ² ; Yu-Jie YIN ³ ; Zhen-Hua JIA ³ ; Yu-Jie YIN ⁴ ; Zhen-Hua JIA ⁴ ; Yu-Jie YIN ⁵ ; Zhen-Hua JIA ⁵ ; Ya-Fen WANG ⁶ ; Zhen-Hua JIA ⁶
Author Information

1. Graduate School, He bei Medical University
2. Hebei Yiling Hospital
3. National Key Laboratory for Innovation and Transformation of Luobing, Theory
4. Key Research Laboratory of National Administration of Traditional Chinese Medicine, Cardio-Cerebral Vessel Collateral Disease
5. Hebei Institute of Integrative Traditional Chinese and Western Medicine
6. Graduate School, Hebei University of Chinese Medicine
Publication Type:Journal Article
Keywords: endothelial cells; endothelium-to-interstitial transdifferentiation; liver fibrosis; myocardial fibrosis; Notch signaling pathway; pulmonary fibrosis; TGF-[3 signaling pathway
From: Chinese Pharmacological Bulletin 2023;39(6):1014-1019
CountryChina
Language:Chinese
Abstract: Fibrosis is a repair response initiated by tissues and organs after injury, and is a self-protection mechanism of the body. It has been found that endothelium-to-interstitial transdifferentiation (EndMT) is involved in the physiological and pathological processes of various organ fibrosis, which has become a focus of the research on fibrotic diseases. In recent years, the study has found that EndMT plays an important role in many pathological processes in cardiovascular system, lungs, kidneys, liver, pancreas fibrosis, and so on. This article summarizes EndMT regulatory mechanism and its role in each organ fibrosis, as well as the related treatment progress of EndMT targets, so as to provide new targets for prevention and control of organ fibrosis.